Anti-angiogenic activity of mangostins isolated from Thailand stingless bee propolis

We conducted functional evaluation and identification of Thailand stingless bee propolis components. Among its nine isolated xanthones, α-mangostin and γ-mangostin were shown to strongly inhibit tube formation of human umbilical vein endothelial cells, an indication of antiangiogenic activity in vitro. We further investigated their effects at the molecular level to understand why they inhibited angiogenesis. (Collaborators: Eriko Ishizu-Nagashima, Sari Honda, Boonyadist Vongsak, Shigenori Kumazawa)