Many commercial preparations have been developed due to the determination of the beneficial biological effects of propolis in the health field. In these propolis products, different solvents are used in extraction and in the final product. It is thought that long-term use of these solvents can damage vital tissues such as the liver. The aim of this study is to determine the effects of using commercial propolis extracts that are widely used and sold for one to three months on liver enzymes. In the study, 56 adult female Wistar albino rats were divided into 7 groups. For 30 and 90 days, propolis ethyl alcohol, propylene
glycol and oil and water-based propolis (250 mg / kg / day) were given to the groups orally by gavage. At the end of the research, liver enzyme levels such as GGT, AST, ALT, ALP were determined in blood samples taken from rats. According to the results obtained; At the end of the first month, the enzyme activities of the rats in the alcohol-based propolis group were found to be significantly higher than those of the control and other groups in terms of LDH, AST, ALT and ALP enzymes.